New research indicates that people who stop using popular slimming jabs like semaglutide or tirzepatide tend to recover lost weight much more quickly than those who end conventional diet and exercise regimens.
Findings released in a major health publication points out that while obese individuals can lose about a fifth of their total mass while undergoing treatment, the weight is regained at an estimated rate of nearly a kilo each month once they quit.
"Individuals buying such medications must be aware of the potential of rapid weight regain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
That rate of recovery implies a reversion to starting mass within about 18 months.
Analyzing Therapies
The analysis, which reviewed 37 of studies involving over 9,000 of patients, compared the results of these new drugs with conventional dieting.
The team note that people who shed pounds through diet and exercise generally experience a more gradual weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Rapid Regain
Experts believe the mode of action of the injections is key to understanding the accelerated weight return.
GLP-1 drugs mimic a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 levels several times higher than normal could lead to the body to produce less of its endogenous hormone, and could lessen responsiveness to its actions," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this GLP-1 'fix' leads to appetite is unsuppressed, making overeating a significant risk."
A Chronic Condition?
Medical guidelines suggest the injections for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, due to the significant potential of weight regain, the treatment is often long-term.
This perspective is supported by pharmaceutical companies, who note that the results "underscore the chronic nature of excess weight," similar to managing conditions like high blood pressure.
Patient Accounts
Individuals who have discontinued the medication describe a powerful resurgence of cravings.
"It felt as if something that goes on and you become ravenous," said a patient.
This challenge is worsened if patients have not adopted permanent dietary or behavioural changes during treatment.
Widespread Interest
Survey data suggest that a significant number of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is greater among females than men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
Ultimately, researchers emphasize that while the jabs are effective tools for weight loss, they are not a standalone solution and maintained weight loss likely depends on ongoing behavioural support.
